Rapalogues-Rapamycin Derivative

Rapamycin or Sirolimus is a macrolide antibiotic identified on Easter Island produced by Streptomyces hygoscopius. At high doses it is an immune suppressor and used for transplant rejection. At low doses, it improves the immune system, is antifungal, anti-inflammatory, antitumor, improves sugar control, improves psoriasis, hearing loss, cardiac inflammatory disease and more. It has been demonstrated to extend life span and delay the onset of age-related disease in animals–even when the animals started at late age. Its mechanism of action is through mTOR, or Mammalian target of rapamycin kinase. There are two distinct complexes, mTORC1 and mTORC2. MTORC1 is a key regulator of protein translation and autophagy. It senses signals from growth factors and nutrients to control cell growth and metabolism. Human clinical trials demonstrate improved immune function, an important target since aging weakens the immune system. Here at The P-treatment, we recommend a pulse of Rapamycin weekly to bi-monthly to certain patients. In particular, those with mitochondrial dysfunction benefit greatly. Mitochondrial stress response is controlled by mTORC1 in muscle. Inhibiting mTORC1 improves all symptoms of skeletal mitochondrial dysfunction leading to increased energy and strength.

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