Exosomes

What are exosomes?

EXOSOMES are tiny vesicles, 40-100nm, that carry signaling information. In a way Exosomes are postal service delivering packages. Inside the packages are biomolecules such as mRNA, miRNA and proteins. In turn these trigger the recipient cell to increase Cytokines and Chemokines.

Most Exosomes used in the regenerative world come from umbilical or placental sources. This is because it is understood that the messages inside the Exosome given to a newborn are essentially for growth and health.

Research has validated Exosome treatments with positive findings of tissue regeneration. In fact, there are thousands of studies regarding Exosome success that range from reducing intrauterine adhesions, to decreasing arthritis, and to improving erectile function. Exosomes have broad therapeutic effects.

The P treatment uses Exosomes for skin and wound healing. However, even topical application allows for Exosomes to enter the body with far reaching health benefits.

Exsosomes have several advantages compared to stem cells.

Advantages:

• Can travel via systemic therapy without risk of clumping
• Can travel via local therapy
• Able to cross the “Blood-Brain Barrier”
• Deliver miRNA and mRNA
• Can home to a particular area
• Not perceived as foreign
• No first-pass lung removal as in MSCs
• Can not transdifferentiate into other cells or into malignant cells
• Easy to administer, store, and freeze
• Easily controlled dosage
• Potency related to age of parent MSC

Actions: 

• Influence Growth of Target Cells
• Influence Phenotype
• Contribute to Cell Fate Decision
• Promote Regeneration
• Immuno-modulation
• Anti-Inflammatory
• Anti-Fibrotic